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Article

Identification of the immune gene expression signature associated with recurrence of high-grade gliomas.

Journal of molecular medicine (Berlin, Germany) - 1 Feb 2021

Roura Adria-Jaume, Gielniewski Bartlomiej, Pilanc Paulina, Szadkowska Paulina, Maleszewska Marta, Krol Sylwia K, Czepko Ryszard, Kaspera Wojciech, Wojtas Bartosz, Kaminska Bozena

Abstract excerpt

High-grade gliomas (HGGs), the most common and aggressive primary brain tumors in adults, inevitably recur due to incomplete surgery or resistance to therapy. Intratumoral genomic and cellular heterogeneity of HGGs contributes to therapeutic resistance, recurrence, and poor clinical outcomes. Transcriptomic profiles of HGGs at recurrence have not been investigated in detail. Using targeted sequencing of...

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PMID: 33215304
DOI: 10.1007/s00109-020-02005-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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