Article
Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Dec 2024
Ouyang Shumin, Shi Shuo, Ding Wen, Ge Yang, Su Yingxue, Mo Jianshan, Peng Keren, Zhang Qiyi, Liu Guopin, Xiao Wei, Yue Peibin, Lu Jinjian, Wang Yandong, Xiong Xiaofeng, Zhang Xiaolei
Abstract excerpt
Uveal melanoma (UM), the predominant primary ocular malignancy, often progresses to liver metastasis with limited therapeutic options. The interplay of the tumor microenvironment, encompassing secreted soluble factors, plays a crucial role in facilitating liver metastasis. In this study, the role is elucidated of the neural growth factor-inducible gene (VGF), a secreted neuropeptide precursor, in Gαq mutant UM....
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