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Novel Genetic Susceptibility Markers for Breast Cancer in Iraqi Women: First Evidence of CYP3A4*1B Protective Effects and GSTP1/MTHFR Risk Associations.

Clinical breast cancer - 1 Mar 2026

Hoidy Wisam Hindawi, Orabiy Mohammed Ouda, Essa Shaimaa Mohsen, Jasim Layth Samir

Abstract excerpt

BACKGROUND: This is the first study looking at breast cancer risk using the polymorphisms CYP3A4*1B, GSTP1 Ile105Val, MTHFR C677T, and COMT Val158Met for breast cancer predisposed Iraqi population with specific environmental carcinogenic exposures. METHODS: Aged matched healthy controls were 610 individuals of Iraqi origin alongside 414 histologically confirmed breast cancer patients forming a case-control study...

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Source

Identifiers

PMID: 41188087
DOI: 10.1016/j.clbc.2025.10.004

Genes

CYP3A4
GSTP1
MTHFR
COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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