Association of the rs9896052 Polymorphism Upstream of GRB2 with Proliferative Diabetic Retinopathy in Patients with Less than 10 Years of Diabetes.

doi:10.3390/ijms251910232

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Article

Association of the rs9896052 Polymorphism Upstream of GRB2 with Proliferative Diabetic Retinopathy in Patients with Less than 10 Years of Diabetes.

International journal of molecular sciences - 24 Sept 2024

Bastos Caroline Moura Cardoso, da Silva Machado Lucas Marcelo, Crispim Daisy, Canani Luís Henrique, Dos Santos Kátia Gonçalves

Abstract excerpt

Growth factor receptor-bound protein 2 (GRB2) is a negative regulator of insulin signaling and a positive regulator of angiogenesis. Its expression is increased in a mouse model of retinal neovascularization and in patients with type 2 diabetes mellitus (T2DM). This case-control study aimed to investigate the association between the rs9896052 polymorphism (A>C) upstream of GRB2 and proliferative diabetic...

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PMID: 39408563
DOI: 10.3390/ijms251910232
PMCID: PMC11477274

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