Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene.

doi:10.1007/s00125-015-3697-2

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Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene.

Diabetologia - 1 Oct 2015

Burdon Kathryn P, Fogarty Rhys D, Shen Weiyong, Abhary Sotoodeh, Kaidonis Georgia, Appukuttan Binoy, Hewitt Alex W, Sharma Shiwani, Daniell Mark, Essex Rohan W, Chang John H, Klebe Sonja, Lake Stewart R, Pal Bishwanath, Jenkins Alicia, Govindarjan Gowthaman, Sundaresan Periasamy, Lamoureux Ecosse L, Ramasamy Kim, Pefkianaki Maria, Hykin Philip G, Petrovsky Nikolai, Brown Matthew A, Gillies Mark C, Craig Jamie E

Abstract excerpt

AIMS/HYPOTHESIS: Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic factors have not yet been identified. Here, we aimed to identify novel genetic risk factors for sight-threatening diabetic retinopathy using a genome-wide association study. METHODS: Retinopathy...

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PMID: 26188370
DOI: 10.1007/s00125-015-3697-2

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GRB2

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