Article
Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy.
Journal of biomedicine & biotechnology - 1 Jan 2009
Costa Valerio, Casamassimi Amelia, Esposito Katherine, Villani Angela, Capone Mariaelena, Iannella Rosa, Schisano Bruno, Ciotola Miryam, Di Palo Carmen, Corrado Feliciantonia Capone, Santangelo Franco, Giugliano Dario, Ciccodicola Alfredo
Abstract excerpt
Peroxisome proliferator-activated receptor gamma polymorphisms have been widely associated with type 2 diabetes, although their role in the pathogenesis of vascular complications is not yet demonstrated. In this study, a cohort of 211 type 2 diabetes, 205 obese, and 254 control individuals was genotyped for Pro12Ala, C1431T, C-2821T polymorphisms, and for a newly identified polymorphism (A-2819G). The...
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