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Article

Mutations in the mitochondrial DNA D-loop region and breast cancer risk.

Breast cancer research and treatment - 1 Jan 2010

Ye Chuanzhong, Shu Xiao Ou, Pierce Larry, Wen Wanqing, Courtney Regina, Gao Yu-Tang, Zheng Wei, Cai Qiuyin

Abstract excerpt

Mitochondrial genome alterations have been suggested to play an important role in carcinogenesis. The D-loop region of mitochondrial DNA (mtDNA) contains essential transcription and replication elements, and mutations in this region may serve as a potential sensor for cellular DNA damage and a marker for cancer development. Using data and samples from the Shanghai Breast Cancer Study, we investigated MnlI...

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Identifiers

PMID: 19381801
DOI: 10.1007/s10549-009-0397-y
PMCID: PMC2796283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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