Article
Focus on the heterogeneity of amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Nov 2020
Bendotti Caterina, Bonetto Valentina, Pupillo Elisabetta, Logroscino Giancarlo, Al-Chalabi Ammar, Lunetta Christian, Riva Nilo, Mora Gabriela, Lauria Giuseppe, Weishaupt Jochen H, Agosta Federica, Malaspina Andrea, Basso Manuela, Greensmith Linda, Van Den Bosch Ludo, Ratti Antonia, Corbo Massimo, Hardiman Orla, Chiò Adriano, Silani Vincenzo, Beghi Ettore
Abstract excerpt
The clinical manifestations of amyotrophic lateral sclerosis (ALS) are variable in terms of age at disease onset, site of onset, progression of symptoms, motor neuron involvement, and the occurrence of cognitive and behavioral changes. Genetic background is a key determinant of the ALS phenotype. The mortality of the disease also varies with the ancestral origin of the affected population and environmental...
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