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Genomic Correlation, Shared Loci, and Causal Relationship Between Bullous Pemphigoid and Atopic Dermatitis: A Large-Scale Genome-Wide Cross-Trait Analysis.

Molecular genetics & genomic medicine - 1 Oct 2024

Wang Qing, Wang Xuehua, Zhuang Qizhen, Wu Yuan, Zhang Junhong, Lu Yue, Wu Jingjing, Liu Juanjuan, Hu Xiangyu, Han Ling

Abstract excerpt

BACKGROUND: Bullous pemphigoid (BP) and atopic dermatitis (AD) are currently thought to be tightly related, yet studies of the mechanisms of co-morbidities are lacking. METHODS: We obtained GWAS data for BP (N = 376,274) and AD (N = 796,661) from the Finnish Genetic Research Program dataset and the UK Biobank, separately. Then, the following four analyses were performed: (1) cross-trait linkage disequilibrium...

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PMID: 39400531
DOI: 10.1002/mgg3.70022
PMCID: PMC11476245

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