Prediction of metachronous advanced colorectal neoplasia by KRAS mutation in polyps.

doi:10.1002/ueg2.12667

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Prediction of metachronous advanced colorectal neoplasia by KRAS mutation in polyps.

United European gastroenterology journal - 1 Nov 2024

Martínez-Roca Alejandro, Cubiella Joaquín, García-Heredia Anabel, Guill-Berbegal David, Baile-Maxía Sandra, Mangas-Sanjuán Carolina, Sala-Miquel Noelia, Madero-Velazquez Lucía, Alenda Cristina, Zapater Pedro, González-Núñez Clara, Iglesias-Gómez Agueda, Codesido-Prado Laura, Díez-Martín Astrid, Kaminski Michal F, Erichsen Rune, Adami Hans-Olov, Ferlitsch Monika, Pellisé María, Holme Øyvind, Dekker Evelien, Bretthauer Michael, Jover Rodrigo

Abstract excerpt

BACKGROUND: The potential of molecular markers in the removed polys as reliable predictors of metachronous lesions is still uncertain. AIM: Our aim was to evaluate the role of somatic mutations in KRAS in polyps of patients with high-risk adenomas to predict the risk of advanced polyps or colorectal cancer (CRC) within 3 years. METHODS: A total of 518 patients were prospectively enrolled. The included patients...

Topics

Humans
Male
Female
Colorectal Neoplasms
Proto-Oncogene Proteins p21(ras)
Middle Aged
Mutation
Colonic Polyps

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Colonoscopy

Prospective Studies

Adenoma

Neoplasms, Second Primary

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 39400528
DOI: 10.1002/ueg2.12667
PMCID: PMC11578838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prediction of metachronous advanced colorectal neoplasia by KRAS mutation in polyps.PMID 39400528Read ↗

KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia.Semantic proximity Read ↗

KRAS and BRAF mutations and MSI status in precursor lesions of colorectal cancer detected by colonoscopy.Semantic proximity Read ↗

Classical driver mutations are not associated with metachronous lesion risk in patients undergoing post-polypectomy surveillance following removal of conventional adenomas in a bowel screening settingSemantic proximity Read ↗

Characteristics of advanced- and non advanced sporadic polypoid colorectal adenomas: correlation to KRAS mutations.Semantic proximity Read ↗

Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer.Semantic proximity Read ↗

Somatic targeted mutation profiling of colorectal cancer precursor lesionsSemantic proximity Read ↗

Critical Role of p53 and K-ras in the Diagnosis of Early Colorectal Cancer: a One-year, Single-center Analysis.Semantic proximity Read ↗

Somatic targeted mutation profiling of colorectal cancer precursor lesions.Semantic proximity Read ↗

KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype.Semantic proximity Read ↗

Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.Semantic proximity Read ↗

Clinicopathologic distribution of KRAS and BRAF mutations in a Chinese population with colorectal cancer precursor lesions.Semantic proximity Read ↗

BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.