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Article

Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatment.

EBioMedicine - 1 Nov 2024

Izquierdo-Lara Ray W, Villabruna Nele, Hesselink Dennis A, Schapendonk Claudia M E, Ribó Pons Sol, Nieuwenhuijse David, Meier Jenny I J, Goodfellow Ian, Dalm Virgil A S H, Fraaij Pieter L A, van Kampen Jeroen J A, Koopmans Marion P G, de Graaf Miranda

Abstract excerpt

BACKGROUND: Currently, there is no licensed treatment for chronic norovirus infections, but the use of intra-duodenally-delivered immunoglobulins is promising; nevertheless, varying results have limited their wide use. Little is known about the relationship between norovirus genetic diversity and treatment efficacy. METHODS: We analyzed the norovirus within-host diversity and evolution in a cohort of 20...

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Identifiers

PMID: 39396425
DOI: 10.1016/j.ebiom.2024.105391
PMCID: PMC11663770

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