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Dual spatial host-bacterial gene expression in Mycobacterium abscessus respiratory infections

9 Oct 2024

Abstract excerpt

Co-localization of spatial transcriptome information of host and pathogen can revolutionize our understanding of microbial pathogenesis. Here, we aimed to demonstrate that customized bacterial probes can be successfully used to identify host-pathogen interactions in formalin-fixed-paraffin-embedded (FFPE) tissues by probe-based spatial transcriptomics technology. We analyzed the spatial gene expression of...

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PMID: 39384974
DOI: 10.1038/s42003-024-06929-5

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