Article

Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response

2018-06-22

Abstract excerpt

<h4>Summary</h4> To understand how the interaction between an intracellular bacterium and the host immune system contributes to outcome at the site of infection, we studied leprosy, a disease that forms a clinical spectrum, in which progressive infection by the intracellular bacterium Mycobacterium leprae is characterized by the production of type | IFNs and antibody production. We performed dual RNAseq on patie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91cad0ba-b332-5efc-8fea-a0f79b752dab
DOI: 10.1101/354407

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune responseDOI 10.1101/354407Read

Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune ResponseSemantic proximity Read

A new paradigm for leprosy diagnosis based on host gene expression Insights from leprosy lesions transcriptomicsSemantic proximity Read

A new paradigm for leprosy diagnosis based on host gene expressionSemantic proximity Read

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy GranulomasSemantic proximity Read

The immune-suppressive landscape in lepromatous leprosy revealed by single-cell RNA sequencingSemantic proximity Read

Integrative immune analysis in patients with leprosy reveals host factors associated with mycobacterial controlSemantic proximity Read

Blood RNA signature RISK4LEP predicts leprosy years before clinical onsetSemantic proximity Read

<i>Mycobacterium leprae</i> and host immune transcriptomic signatures for reactional states in leprosySemantic proximity Read

Dual spatial host-bacterial gene expression in Mycobacterium abscessus respiratory infectionsSemantic proximity Read

Type 1 reaction leprosy patients display distinct immune-regulatory capacity before onset of symptomsSemantic proximity Read

Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter studySemantic proximity Read

Genome-Wide Screening of mRNA Expression in Leprosy PatientsSemantic proximity Read