Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry.

doi:10.1126/science.abm8143

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Article

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry.

Science (New York, N.Y.) - 28 Jan 2022

Park Young-Jun, De Marco Anna, Starr Tyler N, Liu Zhuoming, Pinto Dora, Walls Alexandra C, Zatta Fabrizia, Zepeda Samantha K, Bowen John E, Sprouse Kaitlin R, Joshi Anshu, Giurdanella Martina, Guarino Barbara, Noack Julia, Abdelnabi Rana, Foo Shi-Yan Caroline, Rosen Laura E, Lempp Florian A, Benigni Fabio, Snell Gyorgy, Neyts Johan, Whelan Sean P J, Virgin Herbert W, Bloom Jesse D, Corti Davide, Pizzuto Matteo Samuele, Veesler David

Abstract excerpt

Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures against SARS-CoV-2 variants and future zoonotic sarbecoviruses. We describe the isolation and characterization of a human monoclonal antibody, designated S2K146, that broadly neutralizes viruses belonging to SARS-CoV- and SARS-CoV-2-related sarbecovirus clades which use ACE2 as an entry receptor. Structural and...

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Identifiers

PMID: 34990214
DOI: 10.1126/science.abm8143
PMCID: PMC9400459

Genes

ACE2

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