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Article

Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism.

Cell communication and signaling : CCS - 13 Nov 2023

Lin Li, Ye Yuhong, Fu Haidong, Gu Weizhong, Zhao Manli, Sun Jingmiao, Cao Zhongkai, Huang Guoping, Xie Yi, Liu Fei, Li Lu, Li Qiuyu, Mao Jianhua, Hu Lidan

Abstract excerpt

BACKGROUND: Steroid-resistant nephrotic syndrome (SRNS) is characterized by unrelieved proteinuria after an initial 4-8 weeks of glucocorticoid therapy. Genes in podocytes play an important role in causing SRNS. OBJECTIVE: This study aimed to report a pathogenic mutation in SRNS patients and investigate its effects on podocytes, as well as the pathogenic mechanism. METHODS: We screened out a novel mutation by...

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Identifiers

PMID: 37957688
DOI: 10.1186/s12964-023-01218-w
PMCID: PMC10644598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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