Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci.

doi:10.1093/genetics/135.4.1003

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Article

Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci.

Genetics - 1 Dec 1993

Ebert R H, Cherkasova V A, Dennis R A, Wu J H, Ruggles S, Perrin T E, Shmookler Reis R J

Abstract excerpt

We have used chromosome mapping with polymorphic markers to define genetic components governing life span in the nematode Caenorhabditis elegans. A complex recombinant-inbred population was derived from an interstrain cross, yielding > 1000 genotypes, each a composite of homozygous segments from the two parental strains. Genotypes were analyzed for the last-surviving 1-5% of worms in aging cohorts, and for young...

Topics

Animals
Caenorhabditis elegans
Chromosome Mapping
Genotype
Longevity
Polymerase Chain Reaction
Recombination, Genetic

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Identifiers

PMID: 8307318
DOI: 10.1093/genetics/135.4.1003
PMCID: PMC1205733

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