Article
The genomic and transcriptomic landscape of metastastic urothelial cancer.
Nature communications - 4 Oct 2024
Loriot Yohann, Kamal Maud, Syx Laurene, Nicolle Remy, Dupain Celia, Menssouri Naoual, Duquesne Igor, Lavaud Pernelle, Nicotra Claudio, Ngocamus Maud, Lacroix Ludovic, Tselikas Lambros, Crehange Gilles, Friboulet Luc, Castel-Ajgal Zahra, Neuzillet Yann, Borcoman Edith, Beuzeboc Philippe, Marret Grégoire, Gutman Tom, Wong Jennifer, Radvanyi Francois, Dureau Sylvain, Scoazec Jean-Yves, Servant Nicolas, Allory Yves, Besse Benjamin, Andre Fabrice, Le Tourneau Christophe, Massard Christophe, Bieche Ivan
Abstract excerpt
Metastatic urothelial carcinoma (mUC) is a lethal cancer, with limited therapeutic options. Large-scale studies in early settings provided critical insights into the genomic and transcriptomic characteristics of non-metastatic UC. The genomic landscape of mUC remains however unclear. Using Whole Exome (WES) and mRNA sequencing (RNA-seq) performed on metastatic biopsies from 111 patients, we show that driver...
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