Article
Clinical Outcomes, Genomic Heterogeneity, and Therapeutic Considerations Across Histologic Subtypes of Urothelial Carcinoma.
European urology - 1 Nov 2025
Chu Carissa E, Chen Ziyu, Whiting Karissa, Ostrovnaya Irina, Lenis Andrew T, Clinton Timothy N, Rammal Rayan, Ozcan Gamze Gokturk, Akbulut Dilara, Basar Merve, Chen Jie-Fu, Chen Ying-Bei, Gopalan Anuradha, Fine Samson W, Tickoo Satish K, Arcila Maria, Brannon A Rose, Berger Michael F, Cha Eugene K, Goh Alvin C, Donahue Timothy F, Bajorin Dean F, Teo Min Yuen, Rosenberg Jonathan E, Iyer Gopa, Pietzak Eugene J, Bochner Bernard H, Reuter Victor E, Sarungbam Judy, Solit David B, Al-Ahmadie Hikmat
Abstract excerpt
BACKGROUND AND OBJECTIVE: Divergent differentiation and histologic subtypes are common findings in urothelial carcinoma (UC). Clinically relevant genomic alterations and oncogenic drivers of individual subtypes remain poorly defined. We characterized surgical outcomes and the genomic landscape of UC with aberrant histology (UCAH), with a focus on biomarkers and targetable alterations. METHODS: The clinical cohort...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.