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Article

The evolutionary history of metastatic pancreatic neuroendocrine tumours reveals a therapy driven route to high-grade transformation.

The Journal of pathology - 1 Dec 2024

Backman Samuel, Botling Johan, Nord Helena, Ghosal Suman, Stålberg Peter, Juhlin C Christofer, Almlöf Jonas, Sundin Anders, Zhang Liang, Moens Lotte, Eriksson Barbro, Welin Staffan, Hellman Per, Skogseid Britt, Pacak Karel, Mollazadegan Kazhan, Åkerström Tobias, Crona Joakim

Abstract excerpt

Tumour evolution with acquisition of more aggressive disease characteristics is a hallmark of disseminated cancer. Metastatic pancreatic neuroendocrine tumours (PanNETs) in particular may progress from a low/intermediate to a high-grade disease. The aim of this work was to understand the molecular mechanisms underlying metastatic progression as well as PanNET transformation from a low/intermediate to a high-grade...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39360347
DOI: 10.1002/path.6348

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