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Article

Using epigenetic mechanisms to understand the impact of common disease causing alleles.

Current opinion in immunology - 1 Oct 2012

Leung Amy, Schones Dustin E, Natarajan Rama

Abstract excerpt

Many common genetic variants have been identified to be associated with autoimmune diseases such as Type I diabetes. Methods to identify these genetic loci have become powerful, but deciphering the functional effects of these variants in disease progression remains a major challenge. Recent studies have shown that single nucleotide polymorphisms are associated with altered DNA methylation and chromatin...

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Share to Alleles
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

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Share to Genome-Wide Association Study

Source

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Identifiers

PMID: 22857822
DOI: 10.1016/j.coi.2012.07.004
PMCID: PMC3478440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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