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Article

Shared Genetic Basis, Biological Function and Causal Relationship Between Sleep Traits and Hypothyroidism: Evidence from a Comprehensive Genetic Analysis.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Shi Yinli, Guo Ming, Wang Yuedan, Zeng Guoduan, Li Wenting, Wu Mianhua, Li Bo

Abstract excerpt

BACKGROUND: This research attempts to clarify whether there are any genetic similarities between sleep traits and hypothyroidism based on publicly accessible large-scale genomewide association studies. METHODS: The methodology included colocalization analysis, cross-phenotype association analysis, and linkage disequilibrium score regression analysis to find common genetic overlap. Through tissue function...

Read the complete abstract on PubMed

Topics

Humans
Hypothyroidism
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Sleep
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sleep Duration

Mendelian Randomization Analysis

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 40183266
DOI: 10.2174/0118715303348704250227014802
PMCID: PMC13523181

Genes

MAGI3

Provenance

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