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Methylation, Gene Expression, and Risk Genotypes at the TERT-CLPTM1L Locus in Cervical Cancer.

Molecular carcinogenesis - 1 Jan 2025

Ramachandran Dhanya, Mao Qianqian, Liao Dandan, Kamal Maud, Schürmann Peter, Eisenblätter Rieke, Geffers Robert, Balint Balazs, Lecompte Lolita, Servant Nicolas, Chérif Linda Larbi, Lamy Constance, Baulande Sylvain, Legoix Patricia, Le Tourneau Christophe, Latouche Aurélien, Hillemanns Peter, Scholl Suzy, Dörk Thilo

Abstract excerpt

The reverse transcriptase subunit of telomerase, TERT, is frequently activated in high-grade dysplasia and invasive cancers of the uterine cervix. Telomerase activation through hypomethylation of the TERT promoter holds promise as a biomarker for cervical cancer progression, however, specific CpG sites involved in cervical cancer risk remain to be fully defined. A recent genome-wide association study on cervical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39352309
DOI: 10.1002/mc.23822

Genes

TERT
CLPTM1L

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Methylation, Gene Expression, and Risk Genotypes at the TERT-CLPTM1L Locus in Cervical Cancer.PMID 39352309Read ↗

Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population.Semantic proximity Read ↗

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers.Semantic proximity Read ↗

The identification of two regulatory ESCC susceptibility genetic variants in the TERT-CLPTM1L loci.Semantic proximity Read ↗

Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.Semantic proximity Read ↗

DNA hypermethylation within TERT promoter upregulates TERT expression in cancerSemantic proximity Read ↗

Pervasive promoter hypermethylation of silenced <i>TERT</i> alleles in human cancersSemantic proximity Read ↗

Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines.Semantic proximity Read ↗

Targeted Long-Read Bisulfite Sequencing Identifies Differences in the TERT Promoter Methylation Profiles between TERT Wild-Type and TERT Mutant Cancer CellsSemantic proximity Read ↗

The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium.Semantic proximity Read ↗

DNA methylation of the TERT promoter and its impact on human cancerSemantic proximity Read ↗

Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.Semantic proximity Read ↗

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