Article
The identification of two regulatory ESCC susceptibility genetic variants in the TERT-CLPTM1L loci.
Oncotarget - 2 Feb 2016
Zhou Liqing, Fu Guobin, Wei Jinyu, Shi Juan, Pan Wenting, Ren Yanli, Xiong Xiangyu, Xia Jianhong, Shen Yue, Li Hongliang, Yang Ming
Abstract excerpt
The chromosome 5p15.33 TERT-CLPTM1L region has been identified by genome-wide association studies as a susceptibility locus of multiple malignancies. However, the involvement of this locus in esophageal squamous cell carcinoma (ESCC) development is still largely unclear. We fine-mapped the TERT-CLPTM1L region through genotyping 15 haplotype-tagging single nucleotide polymorphisms (htSNPs) using a two stage...
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