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Article

Differential modulation of mutant CALR and JAK2 V617F-driven oncogenesis by HLA genotype in myeloproliferative neoplasms.

Frontiers in immunology - 1 Jan 2024

Shivarov Velizar, Tsvetkova Gergana, Micheva Ilina, Hadjiev Evgueniy, Petrova Jasmina, Ivanova Anela, Madjarova Galia, Ivanova Milena

Abstract excerpt

It has been demonstrated previously that human leukocyte antigen class I (HLA-I) and class II (HLA-II) alleles may modulate JAK2 V617F and CALR mutation (CALRmut)-associated oncogenesis in myeloproliferative neoplasms (MPNs). However, the role of immunogenetic factors in MPNs remains underexplored. We aimed to investigate the potential involvement of HLA genes in CALRmut+ MPNs. High-resolution genotyping of HLA-I...

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Identifiers

PMID: 39351227
DOI: 10.3389/fimmu.2024.1427810
PMCID: PMC11439724

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