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Article

Probable HLA-mediated immunoediting of JAK2 V617F-driven oncogenesis.

Experimental hematology - 1 Dec 2020

Ivanova Milena, Tsvetkova Gergana, Lukanov Tsvetelin, Stoimenov Angel, Hadjiev Evgueniy, Shivarov Velizar

Abstract excerpt

Human leukocyte antigen class I (HLA-I) genotype has been found to influence cancer development through the presentation of mutational neoepitopes. However, our understanding of its effect on the development of myeloproliferative neoplasms (MPNs) remains limited. We aimed to elucidate the putative protective role of HLA-I alleles in the development of JAK2 V617F-driven MPNs using a population genetics approach....

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Identifiers

PMID: 33017633
DOI: 10.1016/j.exphem.2020.09.200

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