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Article

Causal associations of inflammatory proteins and plasma metabolites with Clostridium difficile colitis: A Mendelian randomization study.

Medicine - 21 Nov 2025

Dong Guofeng, Wang Li, Yan Peiling, Luo Yongjian, Wu Jiao

Abstract excerpt

This Mendelian randomization (MR) study investigates the causal relationships between circulating inflammatory proteins, blood metabolites, and Clostridium difficile colitis (CDC), with a focus on potential metabolic mediation. Bidirectional and mediation MR analyses were performed using genome-wide association study (GWAS) summary statistics from 3384 CDC cases and 406,048 controls. The primary MR methods...

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Share to Clostridioides difficile
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41305795
DOI: 10.1097/MD.0000000000045787
PMCID: PMC12643595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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