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Exploring the tolerable region for HiBiT tag insertion in the hepatitis B virus genome

30 Sept 2024

Abstract excerpt

A cell culture system that allows the reproduction of the hepatitis B virus (HBV) life cycle is indispensable to exploring novel anti-HBV agents. To establish the screening system for anti-HBV agents, we exploited the high affinity and bright luminescence (HiBiT) tag and comprehensively explored the regions in the HBV genome where the HiBiT tag could be inserted. The plasmids for the HiBiT-tagged HBV molecular...

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PMID: 39345122
DOI: 10.1128/msphere.00518-24

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