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Article

Neoadjuvant chemotherapy induces phenotypic mast cell changes in high grade serous ovarian cancer.

Journal of ovarian research - 28 Sept 2024

McAdams Julia, Ebott Jasmine, Jansen Corinne, Kim Chloe, Maiz Daniela, Ou Joyce, Hanley Linda C, Cruz Payton De La, James Nicole E

Abstract excerpt

BACKGROUND: High grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in which patients have still yet to respond meaningfully to clinically available immunotherapies. Hence, novel immune targets are urgently needed. Our past work has identified that mast cells are significantly upregulated at the mRNA level in HGSOC patient tumors following neoadjuvant chemotherapy (NACT) exposure....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39342316
DOI: 10.1186/s13048-024-01516-y
PMCID: PMC11438021

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