Article
Integrated analyses of multi-omic data derived from paired primary lung cancer and brain metastasis reveal the metabolic vulnerability as a novel therapeutic target.
Genome medicine - 26 Nov 2024
Duan Hao, Ren Jianlan, Wei Shiyou, Yang Zhenyu, Li Chuan, Wang Zhenning, Li Meichen, Wei Zhi, Liu Yu, Wang Xiuqi, Lan Hongbin, Zeng Zhen, Xie Maodi, Xie Yuan, Wu Suwen, Hu Wanming, Guo Chengcheng, Zhang Xiangheng, Liang Lun, Yu Chengwei, Mou Yanhao, Jiang Yu, Li Houde, Sugarman Eric, Deek Rebecca A, Chen Zexin, Li Tao, Chen Yaohui, Yao Maojin, Chen Likun, Liu Lunxu, Zhang Gao, Mou Yonggao
Abstract excerpt
BACKGROUND: Lung cancer brain metastases (LC-BrMs) are frequently associated with dismal mortality rates in patients with lung cancer; however, standard of care therapies for LC-BrMs are still limited in their efficacy. A deep understanding of molecular mechanisms and tumor microenvironment of LC-BrMs will provide us with new insights into developing novel therapeutics for treating patients with LC-BrMs. METHODS:...
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