Article
Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases.
FEBS letters - 9 Mar 2012
Papa Sergio, Rasmo Domenico De, Technikova-Dobrova Zuzana, Panelli Damiano, Signorile Anna, Scacco Salvatore, Petruzzella Vittoria, Papa Francesco, Palmisano Giuseppe, Gnoni Antonio, Micelli Loris, Sardanelli Anna Maria
Abstract excerpt
In mammals, complex I (NADH-ubiquinone oxidoreductase) of the mitochondrial respiratory chain has 31 supernumerary subunits in addition to the 14 conserved from prokaryotes to humans. Multiplicity of structural protein components, as well as of biogenesis factors, makes complex I a sensible pace-maker of mitochondrial respiration. The work reviewed here shows that the cAMP/PKA pathway regulates the biogenesis,...
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