Article
A New Method for Conditional Gene-Based Analysis Effectively Accounts for the Regional Polygenic Background.
Genes - 7 Sept 2024
Svishcheva Gulnara R, Belonogova Nadezhda M, Kirichenko Anatoly V, Tsepilov Yakov A, Axenovich Tatiana I
Abstract excerpt
Gene-based association analysis is a powerful tool for identifying genes that explain trait variability. An essential step of this analysis is a conditional analysis. It aims to eliminate the influence of SNPs outside the gene, which are in linkage disequilibrium with intragenic SNPs. The popular conditional analysis method, GCTA-COJO, accounts for the influence of several top independently associated SNPs...
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