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Article

Characterization and Phenotypic Assessment of Zebrafish Disease Models for Splice Modulation Studies.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Thomas Holly R, English Katherine G, Alexander Matthew S, Parant John M

Abstract excerpt

Zebrafish has emerged as a powerful model in biomedical research as it recapitulates many human disease pathologies. Zebrafish share approximately 70% evolutionarily conserved genes with humans. Recent advances in genome editing have enabled many precision and inducible models that mimic human disorders to be rapidly generated for phenotypic analysis. The large clutch size, ex vivo development, and ability to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41028679
DOI: 10.1007/978-1-0716-4738-7_7
PMCID: PMC12797569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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