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Article

Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy.

PLoS genetics - 1 Jan 2026

Flannery Kyle P, Mowla Shorbon, Battula Namarata, Clark L Rose, Oliveira Callista D, Simhon Lillian M, Liu Deze, Venkatesan Cynthia, Karas Brittany F, Terez Kristin R, Burbano Daniel, Manzini M Chiara

Abstract excerpt

Genetic compensation is a common phenomenon in zebrafish in response to genetic alterations. Differences between genetic and morpholino-mediated zebrafish models of human diseases have led to significant difficulties in phenotypic interpretation and translatability. One form of compensation is the maternal deposit of mRNAs and proteins to the oocyte that supports developmental processes before zygotic genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41533692
DOI: 10.1371/journal.pgen.1011987
PMCID: PMC12803454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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