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Article

Inactivation of JNK signalling results in polarity loss and cell senescence of Sertoli cell

27 Sept 2024

Abstract excerpt

Abstract As major somatic cells in the testis, Sertoli cell development is precisely regulated by numerous factors, and aberrant development of these cells is associated with male reproductive diseases. JNK signalling is evolutionarily conserved and involved in multiple critical biological processes. Here, we found that the double knockout of Jnk1 and Jnk2 resulted in aberrant localisation of Sertoli cells at...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 39329440
DOI: 10.1111/cpr.13760

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