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TNF-α and RPLP0 driving apoptosis of endothelial cells as the shared molecular mechanism of high altitude pulmonary edema in sojourners and natives: bioinformatic analysis and experimental validation

2024-06-12

Abstract excerpt

<title>Abstract</title> <p>High altitude pulmonary edema (HAPE) is a fatal threat for those sojourners who ascend rapidly without sufficient acclimatization. High altitude natives are insusceptible to HAPE resulting from evolved genetic specializations of adaption. In this study, based on GSE52209, the gene expression profile of HAPE patients was compared with acclimatized sojourners and adapted natives, with the...

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Literature Corpus work: 35902122-8f9e-5ed7-a74e-b6d57b36f32e
DOI: 10.21203/rs.3.rs-4478935/v1

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