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Deciphering the role of tryptophan metabolism-associated genes ECHS1 and ALDH2 in gastric cancer: implications for tumor immunity and personalized therapy

12 Sept 2024

Abstract excerpt

Background Tryptophan Metabolism-associated Genes (TMGs), such as ECHS1 and ALDH2, are crucial in cancer progression through immunosuppressive mechanisms, particularly in Gastric Cancer (GC). This study explores their effects on the Tumor Microenvironment (TME). Additionally, it examines their potential as novel immunotherapy targets. Methods We utilized single-cell and bulk transcriptomic technologies to analyze...

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PMID: 39328412
DOI: 10.3389/fimmu.2024.1460308

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