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Article

Polygenic scores for complex traits are associated with changes in concentration of circulating lipid species.

PLoS biology - 1 Sept 2024

Tabassum Rubina, Mars Nina, Parolo Pietro Della Briotta, Gerl Mathias J, Klose Christian, Pirinen Matti, Simons Kai, Widén Elisabeth, Ripatti Samuli

Abstract excerpt

Understanding perturbations in circulating lipid levels that often occur years or decades before clinical symptoms may enhance our understanding of disease mechanisms and provide novel intervention opportunities. Here, we assessed if polygenic scores (PGSs) for complex traits could detect lipid dysfunctions related to the traits and provide new biological insights. We constructed genome-wide PGSs (approximately 1...

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Identifiers

PMID: 39325819
DOI: 10.1371/journal.pbio.3002830
PMCID: PMC11460696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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