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Article

Impact of Variant Reclassification in Cancer Predisposition Genes on Clinical Care.

JCO precision oncology - 1 Nov 2021

Chiang Jianbang, Chia Tze Hao, Yuen Jeanette, Shaw Tarryn, Li Shao-Tzu, Binte Ishak Nur Diana, Chew Ee Ling, Chong Siao Ting, Chan Sock Hoai, Ngeow Joanne

Abstract excerpt

PURPOSE: Genetic testing has clinical utility in the management of patients with hereditary cancer syndromes. However, the increased likelihood of encountering a variant of uncertain significance in individuals of non-European descent such as Asians may be challenging to both clinicians and patients. This study aims to evaluate the impact of variant reclassification in an Asian country with variants of uncertain...

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Source

Identifiers

PMID: 34994607
DOI: 10.1200/PO.20.00399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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