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Article

How variants of uncertain significance affect clinical decisions: A systematic review.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2026

Ayappa Shiv, Joffe Steven, Laberge Anne-Marie, Nye Russell T, Hess Molly, Callahan Katharine P

Abstract excerpt

PURPOSE: To assess the extent to which variants of uncertain significance (VUS) affect clinical decisions. METHODS: We conducted a systematic review of studies reporting the impact of VUS on clinical decisions. We extracted quantitative data on VUS' impact for grouped analysis. We calculated and compared odds ratios of the specified decisions for patients found to have benign results, VUS, and pathogenic results....

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Identifiers

PMID: 42117370
DOI: 10.1016/j.gim.2026.102593
PMCID: PMC13192372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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