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Clinical and laboratory genetic counselor attitudes on the reporting of variants of uncertain significance for multigene cancer panels.

Journal of genetic counseling - 1 Jun 2023

Chang Emmeline Y, Solomon Ilana, Culver Julie O, Gorman Nicholas, Comeaux Jacob G, Lerman Caryn, Quinn Emily A, Ekstein Tali

Abstract excerpt

Research suggests variants of uncertain significance (VUSs) present a variety of challenges for genetic counselors (GCs), nongenetics clinicians, and patients. Multigene cancer panels reveal more VUSs than single gene testing as a result of the increase in the number of genes being tested. This study surveyed 87 clinical cancer GCs involved with direct patient care and 19 laboratory GCs who provide guidance to...

Topics

Humans
Counselors
Laboratories
Genetic Testing
Neoplasms
Attitude
Genetic Predisposition to Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36747331
DOI: 10.1002/jgc4.1680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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