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Orientia tsutsugamushi infection reduces host gluconeogenic but not glycolytic substrates

26 Sept 2024

Abstract excerpt

ABSTRACT Orientia tsutsugamushi a causal agent of scrub typhus, is an obligate intracellular bacterium that, akin to other rickettsiae, is dependent on host cell-derived nutrients for survival and thus pathogenesis. Based on limited experimental evidence and genome-based in silico predictions, O. tsutsugamushi is hypothesized to parasitize host central carbon metabolism (CCM). Here, we (re-)evaluated O....

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PMID: 39324805
DOI: 10.1128/iai.00284-24

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