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A metabolic dependency for host isoprenoids in the obligate intracellular pathogen <i>Rickettsia parkeri</i> underlies a sensitivity for the statin class of host-targeted therapeutics

2019-01-23

Abstract excerpt

Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it remains largely unknown which nutrients they require and whether their metabolic dependency can be exploited therapeutica...

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Literature Corpus work
00bfe378-8526-5a24-9887-9dcdf0de55af
DOI
10.1101/528018
Open publication

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A metabolic dependency for host isoprenoids in the obligate intracellular pathogen <i>Rickettsia parkeri</i> underlies a sensitivity for the statin class of host-targeted therapeuticsDOI 10.1101/528018
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