Mutant genes in familial Alzheimer's disease and transgenic models.

doi:10.1146/annurev.neuro.21.1.479

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Article

Mutant genes in familial Alzheimer's disease and transgenic models.

Annual review of neuroscience - 1 Jan 1998

Price D L, Sisodia S S

Abstract excerpt

The most common cause of dementia occurring in mid- to late-life is Alzheimer's disease (AD). Some cases of AD, particularly those of early onset, are familial and inherited as autosomal dominant disorders linked to the presence of mutant genes that encode the amyloid precursor protein (APP) or t...

Topics

Alzheimer Disease
Animals
Humans
Mice
Mice, Transgenic
Mutation

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