Article
Mutant genes in familial Alzheimer's disease and transgenic models.
Annual review of neuroscience - 1 Jan 1998
Price D L, Sisodia S S
Abstract excerpt
The most common cause of dementia occurring in mid- to late-life is Alzheimer's disease (AD). Some cases of AD, particularly those of early onset, are familial and inherited as autosomal dominant disorders linked to the presence of mutant genes that encode the amyloid precursor protein (APP) or the presenilins (PS1 or PS2). These mutant gene products cause dysfunction/death of vulnerable populations of nerve...
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