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Article

Scalable production of siRNA-encapsulated extracellular vesicles for the inhibition of KRAS-mutant cancer using acoustic shock waves.

Journal of extracellular vesicles - 1 Sept 2024

Kim Hyo Kyeong, Choi Yujeong, Kim Kyoung Hwa, Byun Yeongju, Kim Tae Hee, Kim Jae Hwan, An Shung Hyun, Bae DaeHo, Choi Myeong Kwan, Lee Minyoung, Kang Gwansuk, Chung Jihwa, Kim Seok-Hyun, Kwon Kihwan

Abstract excerpt

Extracellular vesicles (EVs) have emerged as a potential delivery vehicle for nucleic-acid-based therapeutics, but challenges related to their large-scale production and cargo-loading efficiency have limited their therapeutic potential. To address these issues, we developed a novel "shock wave extracellular vesicles engineering technology" (SWEET) as a non-genetic, scalable manufacturing strategy that uses shock...

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Source

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Identifiers

PMID: 39323378
DOI: 10.1002/jev2.12508
PMCID: PMC11424982

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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