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Article

Sod1-deficient cells are impaired in formation of the modified nucleosides mcm5s2U and yW in tRNA.

RNA (New York, N.Y.) - 18 Nov 2024

Xu Fu, Byström Anders S, Johansson Marcus J O

Abstract excerpt

Uridine residues present at the wobble position of eukaryotic cytosolic tRNAs often carry a 5-carbamoylmethyl (ncm5), 5-methoxycarbonylmethyl (mcm5), or 5-methoxycarbonylhydroxymethyl (mchm5) side-chain. The presence of these side-chains allows proper pairing with cognate codons, and they are particularly important in tRNA species where the U34 residue is also modified with a 2-thio (s2) group. The first step in...

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PMID: 39322276
DOI: 10.1261/rna.080181.124
PMCID: PMC11571800

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