Article
Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions.
Nucleic acids research - 30 Sept 2015
Tigano Marco, Ruotolo Roberta, Dallabona Cristina, Fontanesi Flavia, Barrientos Antoni, Donnini Claudia, Ottonello Simone
Abstract excerpt
To gain a wider view of the pathways that regulate mitochondrial function, we combined the effect of heat stress on respiratory capacity with the discovery potential of a genome-wide screen in Saccharomyces cerevisiae. We identified 105 new genes whose deletion impairs respiratory growth at 37°C by interfering with processes such as transcriptional regulation, ubiquitination and cytosolic tRNA wobble uridine...
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