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Article

Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions.

Molecular cell - 17 Oct 2024

Lee Paul Jongseo, Sun Yu, Soares Alexa R, Fai Caroline, Picciotto Marina R, Guo Junjie U

Abstract excerpt

While many mRNAs contain more than one translation initiation site (TIS), the functions of most alternative TISs and their corresponding protein isoforms (proteoforms) remain undetermined. Here, we showed that alternative usage of CUG and AUG TISs in neuronal pentraxin receptor (NPR) mRNA produced two proteoforms, of which the ratio was regulated by RNA secondary structure and neuronal activity. Downstream AUG...

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Identifiers

PMID: 39317199
DOI: 10.1016/j.molcel.2024.08.032
PMCID: PMC11490368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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