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Article

Multiancestry transferability of a polygenic risk score for diverticulitis.

BMJ open gastroenterology - 23 Sept 2024

Ueland Thomas E, Mosley Jonathan D, Neylan Christopher, Shelley John P, Robinson Jamie, Gamazon Eric R, Maguire Lillias, Peek Richard, Hawkins Alexander T

Abstract excerpt

OBJECTIVE: Polygenic risk scores (PRS) for diverticular disease must be evaluated in diverse cohorts. We sought to explore shared genetic predisposition across the phenome and to assess risk stratification in individuals genetically similar to European, African and Admixed-American reference samples. METHODS: A 44-variant PRS was applied to the All of Us Research Program. Phenome-wide association studies (PheWAS)...

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Identifiers

PMID: 39313293
DOI: 10.1136/bmjgast-2024-001474
PMCID: PMC11418579

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