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Article

Polygenic Risk Prediction in Diverticulitis.

Annals of surgery - 1 Jun 2023

De Roo Ana C, Chen Yanhua, Du Xiaomeng, Handelman Samuel, Byrnes Mary, Regenbogen Scott E, Speliotes Elizabeth K, Maguire Lillias H

Abstract excerpt

OBJECTIVE: To derive and validate a polygenic risk score (PRS) to predict the occurrence and severity of diverticulitis and to understand the potential for incorporation of a PRS in current decision-making. BACKGROUND: PRS quantifies genetic variation into a continuous measure of risk. There is a need for improved risk stratification to guide surgical decision-making that could be fulfilled by PRS. It is unknown...

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PMID: 35876359
DOI: 10.1097/SLA.0000000000005623
PMCID: PMC10874245

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