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Article

Long-Term Stable and Multifeature Microfluidic Impedance Flow Cytometry Based on a Constricted Channel for Single-Cell Mechanical Phenotyping.

Analytical chemistry - 5 Nov 2024

Li Shan-Shan, Xue Chun-Dong, Hu Si-Yu, Li Yong-Jiang, Chen Xiao-Ming, Zhao Yan, Qin Kai-Rong

Abstract excerpt

The microfluidic impedance flow cytometer (m-IFC) using constricted microchannels is an appealing choice for the high-throughput measurement of single-cell mechanical properties. However, channels smaller than the cells are susceptible to irreversible blockage, extremely affecting the stability of the system and the throughput. Meanwhile, the common practice of extracting a single quantitative index, i.e., total...

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PMID: 39431959
DOI: 10.1021/acs.analchem.4c04097

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